metformin treatment in hyperglycemic critically ill patients: another challenge on the control of adverse outcomes

نویسندگان

yunes panahi chemical injuries research center, baqiyatallah medical sciences university, tehran, iran.

mojtaba mojtahedzadeh pharmaceutical research center, tehran university of medical sciences, tehran, iran. faculty of pharmacy, tehran university of medical sciences, tehran, iran.

nuria zekeri faculty of pharmacy, tehran university of medical sciences, tehran, iran.

fatemeh beiraghdar nephrology and urology research center, baqiyatallah medical sciences university, tehran, iran.

چکیده

new-onset hyperglycemia in patients admitted to intensive care units increases the risk of morbidity and mortality. insulin resistance is frequently seen in the treatment of stress-induced hyperglycemia. metformin, an oral anti-hyperglycemic agent, may introduce a new treatment protocol in critically ill patients with insulin-resistance hyperglycemia. fifty-one non-diabetic traumatized patients with blood sugar (bs) levels more than 130 mg/dlwere introducedto three days of treatment with intensive insulin (50 iu) or metformin (1000 mg, twice daily) therapy. clinical evaluationsincluded acute physiological and chronic health evaluation (apache ii) and glasgow coma scale (gcs). experimental tests included bs level, mean arterial pressure (map), ph, hco3, and lactate. eight patients were excluded and 21 of remained patients treated with insulin and 23 with metformin. there was no significant difference in terms of the evaluated factors between the two groups at the time of admission. although desirable bs level (bs < 130 mg/dl) was reached by three days of metformin treatment (p < 0.01),there was no significant difference in bs, map, ph and hco3of insulin treated groupin comparison with metformin treated patients. the findings weresimilar for apache ii and gcs as well. although obvious studies are required, these findings may lead to effective therapies against stress-induced hyperglycemia.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Metformin Treatment in Hyperglycemic Critically Ill Patients: Another Challenge on the Control of Adverse Outcomes

New-onset hyperglycemia in patients admitted to intensive care units increases the risk of morbidity and mortality. Insulin resistance is frequently seen in the treatment of stress-induced hyperglycemia. Metformin, an oral anti-hyperglycemic agent, may introduce a new treatment protocol in critically ill patients with insulin-resistance hyperglycemia. Fifty-one non-diabetic traumatized patients...

متن کامل

Metformin Treatment in Hyperglycemic Critically Ill Patients: Another Challenge on the Control of Adverse Outcomes

New-onset hyperglycemia in patients admitted to intensive care units increases the risk of morbidity and mortality. Insulin resistance is frequently seen in the treatment of stress-induced hyperglycemia. Metformin, an oral anti-hyperglycemic agent, may introduce a new treatment protocol in critically ill patients with insulin-resistance hyperglycemia. Fifty-one non-diabetic traumatized patients...

متن کامل

Metformin Treatment in Hyperglycemic Critically Ill Patients: Another Challenge on the Control of Adverse Outcomes

New-onset hyperglycemia in patients admitted to intensive care units increases the risk of morbidity and mortality. Insulin resistance is frequently seen in the treatment of stress-induced hyperglycemia. Metformin, an oral anti-hyperglycemic agent, may introduce a new treatment protocol in critically ill patients with insulin-resistance hyperglycemia. Fifty-one non-diabetic traumatized patients...

متن کامل

Microalbuminuria in Hyperglycemic Critically Ill Patients Treated with Insulin or Metformin

Microalbuminuria is thought to reflect the severity of inflammation-induced systemic vascular permeability. The present study investigated the effect of early administration of metformin or insulin on microalbuminuria in traumatized critically ill patients. Between April 2006 and October 2007, thirty-one non-diabetics traumatized patients with systemic inflammatory response syndrome (SIRS) and ...

متن کامل

Microalbuminuria in Hyperglycemic Critically Ill Patients Treated with Insulin or Metformin

Microalbuminuria is thought to reflect the severity of inflammation-induced systemic vascular permeability. The present study investigated the effect of early administration of metformin or insulin on microalbuminuria in traumatized critically ill patients. Between April 2006 and October 2007, thirty-one non-diabetics traumatized patients with systemic inflammatory response syndrome (SIRS) and ...

متن کامل

microalbuminuria in hyperglycemic critically ill patients treated with insulin or metformin

microalbuminuria is thought to reflect the severity of inflammation-induced systemic vascular permeability. the present study investigated the effect of early administration of metformin or insulin on microalbuminuria in traumatized critically ill patients. between april 2006 and october 2007, thirty-one non-diabetics traumatized patients with systemic inflammatory response syndrome (sirs) and ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۲۰۱۱، شماره ۴، صفحات ۹۱۳-۹۱۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023